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Molecular docking studies revealed that 77 makes hydrogen bonds with residues Arg880, Thr1010 and Val1011

According to NICE guidance, Mounjaro is recommended for people with: BMI of at least 35 kg/m and at least one weight-related health condition, or BMI of at least 30 kg/m with type 2 diabetes NICE recommends Mounjaro be prescribed alongside a reduced-calorie diet and increased physical activity, with treatment reviewed after 12 months to assess effectiveness 6

MT2 is a cyclic peptide, meaning its amino acid chain is looped back on itself, forming a ring

There are some potential reasons for these controversy including small sample size, unavailability of some patient-related data including smoking and drinking status, age and sex, and finally, a lower linkage disequilibrum (LD) in African population compared to Chinese population [35]